SELE and cancer: Subsequent E-selectin blockade on ECs (with a function-blocking antibody) drastically affected the adhesion capacity of the cancer cells (Fig. 1C): firm adhesions of all cell lines (and the predominant rolling adhesions in case of GC5023 and SKOV3 cells) were strikingly decreased or completely abolished with an exception for HOS (modest, but significant effect) and MV3 (no effect).