The frequent identification of variants in genes associated with known, named syndromes in several families, in a cohort where the key inclusion criterion for sequencing was polymicrogyria irrespective of other features, suggests that the presence of polymicrogyria in a patient is sufficient reason to perform broad sequencing, such as ES, for a family in search of a genetic diagnosis, with the possible exception of polymicrogyria that co-occurs with macrocephaly, in which case a targeted mTOR panel might precede ES. The gene discussed is MTOR; the disease is Macrocephaly.