Sequencing of this cohort contributed to first descriptions of several genes with novel or recent polymicrogyria associations (TMEM161B, SCN2A, KIF26A, QRICH1, PANX1, and MAN2C1), whether as phenotypic expansions of known neurological syndromes or as a syndrome with brain disease for the first time (PANX1). The gene discussed is MAN2C1; the disease is brain disorder.