Strikingly, several studies performed by Winn and colleagues have found that direct binding of WNT7a to WNT receptor FZD9 in NSCLC cells could inhibit cellular transformation and proliferation by increasing the activity of a tumor suppressor PPARγ in a Gα16/ERK5 pathway-dependent manner and resultant disinhibitory effect of MDM2 on p53 tumor suppressor pathway by inducing the expression of anti-cancer miR-29b, and promote epithelial differentiation of these cells through activating JNK pathway and the resultant upregulation of cadherins [115–118]. Here, MAPK8 is linked to non-small cell lung carcinoma.