WNT1 not only accelerates the proliferation of tumors by upregulating c-Myc, but also promotes the tumor malignant proliferation and angiogenesis by inducing the expression of target genes such as Cyclin D1, VEGF-A, and matrix metalloproteinase 7 (MMP7) [45, 46]. The gene discussed is CCND1; the disease is neoplasm.