In addition, regardless of the TNM stage of NSCLC, the increased expression levels of WNT1 and β-catenin foreshadowed poor prognosis of NSCLC patients after surgery, [45] suggesting that the increased expression level of WNT1 is an important mechanism leading to the over-activation of canonical WNT pathway in NSCLC. The gene discussed is WNT1; the disease is non-small cell lung carcinoma.