CCND1 and neoplasm: Therefore, the abnormal signal transduction of the canonical WNT pathway will activate the transcription of a variety of tumor-related target genes, such as c-Myc, Cyclin D1, and vascular endothelial growth factor (VEGF), thereby inducing the malignant transformation of normal cells or promoting the malignant proliferation and metastasis of cancer cells and tumor angiogenesis [37–39].