BIRC5 and lung carcinoma: Therefore, inhibition of WNT2b expression has a potential therapeutic effect on NSCLC, for example, the adenoviral vector carrying shRNA against WNT2b not only induced the apoptosis of several Wnt2b-overexpressing human tumor cells by downregulating c-Myc and survivin, but also exerted a strong antitumor activity in the intrapleural lung cancer model of Wnt2b-overexpressing lung cancer xenografts [71, 72].