Clinical factors associated with increased risk of PCa progression in palpable tumors were PSA, BPC ≥50%, ISUP Grade Group, cN1 and abnormal DRE (HR = 1.902; 95% CI: 1.389–2.605; p < 0.0001), as illustrated in Supplementary material: Figure 1. The gene discussed is KLK3; the disease is posterior cortical atrophy.