SSTR2 and neoplasm: Nevertheless, this observation of SSTR-2 upregulation is still disputable because some studies found no significant differences in 68Ga-DOTATATE tumoral uptake after SSA treatment.16–18 However, one could wonder whether this difference in uptake of 68Ga-DOTATATE could also be explained by the functional state of the tumor, that is, expression of differences in hormonal hypersecretion, implying the clinical need for SSA.