N-terminalLT comprises the DNAJ domain that binds to heat stroke protein, themotif protein binding the LxCxE (RB) of retinoblastoma tumor suppressor,and the conserved region 1 (CR1), which acts like the transformationof a cell area of the adenovirus E1A protein.90 The OBD (Ori binding domain) and the helicase/ATPase domain103,104 are located in the C-terminal region of LT and are essential forinducing viral DNA replication. The gene discussed is RB1; the disease is neoplasm.