Blinded assessment of thechange in the burden of KS lesions, CD4+ T cell count and HIV plasmaHIV RNA levels, KSHV DNA levels in saliva and blood, Humoral and cellularKSHV immune response markers, Quality-of-life assessment, Incidenceof Kaposi’s sarcoma-associated Immune Reconstitution InflammatorySyndrome (KS-IRIS). Here, CD4 is linked to Kaposi's sarcoma.