TP53 and acute promyelocytic leukemia: EBNA1 is essential for replicating and maintaining the EBVgenome and can be used as an oncogene.60 A protein is involved in tumor suppression and regulates p53 activationof PML (Promyelocytic leukemia).77 If PMLinhibits its activity, EBNA1 hinders p53-dependent p21 stimulationand apoptotic signaling, thereby improving cell survival in the caseof DNA scarring.71,77 In addition, EBNA1 can preventcell apoptosis by negatively regulating the expression of the oncogeneMyc and intensifying the expression of antiapoptotic proteins suchas Bcl2 and survivin.68