TGFB1 and hepatocellular carcinoma: The recognitionof other key regulators of liver regeneration initiated by HCV infectionsupports this, which includes signaling of EGFR146,149,150 and IL6/STAT3.179 Furthermore, the Hh activity promotes crosstalk betweenEMT and TGFβ and Wnt signals,180 whichonce again highlights the correlation between the induction of EMTand hepatitis C virus and its repercussions for HCV-related hepaticpathogenesis and the progression of HCC.