To prime T cells, migratory DCs alsopick up antigens in the tumor microenvironment or the periphery and′′transfer′′ them to lymph node-resident DCs.336 It is significant to highlight that the activationof CD8+ T cells and tumor immunity depend heavily on CD4+ T cell support.T cell stemness is becoming increasingly important as a regulatorof tumor immunity and a determinant of the immunotherapy response.After cognate contacts, the activated T cells return to the TME tolimit tumor development by direct killing and IFN-mediated inhibitionof cancer cell proliferation.337. This evidence concerns the gene CD4 and neoplasm.