This clinical parameter reflects body iron states; therefore,it is used for diagnosing both iron deficiency and iron overload incombination with other serum biomarkers such as ferritin, serum solubleTf receptor, and/or hepcidin.1−4 Moreover, a high level of TSAT has been proposedas a biomarker of the risk for various diseases, such as cardiovasculardisease, diabetes mellitus, and cancer,1,2 and even severalclinical and preclinical studies suggest that brain damage inducedby ischemia is increased by a previous systemic iron overload.5−7. The gene discussed is HAMP; the disease is Tangier disease.