EPHA4 and Alzheimer disease: Based on the fact that the PTPRO substrates SRC and EPHA4 are involved in the development of AD, cognitive deficiency, and neuronal differentiation (58–61), it is conceivable that reduced levels of PTPRO lead to phosphorylation/activation of SRC and EPHA4, and therefore the PTPRO/SRC/EPHA4 axis plays what we believe is a previously unrecognized role in CRCI and possibly other cognition-related disorders.