Given that CRCI is particularly frequent in elderly cancer patient populations and PTPRO expression in the hippocampus declines with age (Figure 2), the aged WT female mice (18 months old) were pretreated with BBR (or corn oil) for 4 weeks, followed by exposure to DOX (or saline) injection (Figure 10A), and followed by assays of cognitive-behavioral performance. The gene discussed is PTPRO; the disease is cancer.