BICRA and Alzheimer disease: BICRA exhibited a high probability of loss of function (LoF) intolerance (pLI) score of 0.98 (gnomAD v2.1; Karczewski et al., 2020), classified BICRA as “likely dominant” in DOMINO (Quinodoz et al., 2017) database with the probability of being AD score of 0.68.