However, these studies evaluating the natural history of BC in BRCA1 and BRCA2 carriers usually investigate cases of all BC subtypes together and, due to the intrinsic association of BRCA1 with TNBC and BRCA2 with luminal BC subtypes, it is difficult to define the genuine interplay of the deficiency of each of these genes and the natural history of the disease, regardless of the intrinsic subtype. Here, BRCA2 is linked to breast cancer.