Our previous study demonstrated that acute sleep deprivation increases the enzymatic cleavage of TrkB‐FL, a receptor for brain‐derived neurotrophic factor (BDNF), through activation of the basal forebrain PIEZO1/Ca2+/calpain pathway, leading to curtailed BDNF signaling and memory impairments.19, 20. Here, BDNF is linked to memory impairment.