PIEZO1 and memory impairment: Considering that PIEZO1 mainly acts through Ca2+ signaling,18 which can regulate autophagy through calpain, calcineurin, and CaMKKβ,26, 27 we proposed and tested the hypothesis that EE may regulate PIEZO1/calpain/autophagy signaling pathway in the basal forebrain of mice to alleviate sleep deprivation‐induced memory impairments.