CD14+ macrophages were detected in MSC co‐cultured organoids by immunostaining, while organoids cultured with MSC plus PBMC showed a large number of macrophages as in primary HCC tissues (Figure 4G), indicating that MSC‐PDO‐PBMC co‐culture generated organoids similar to original HCC TME. The gene discussed is CD14; the disease is hepatocellular carcinoma.