One study has reported that TIM‐3 knockdown in vivo significantly increased IFN‐γ production from hepatic CD8+ T cells in the Hepatitis B virus mouse model.[47] In addition, another research studied the effect of TIM‐3 knockout or TIM‐3 overexpression on T cells and confirmed the negative effect of TIM‐3 on T cell responses against acute lymphoblastic leukemia.[48] Therefore, the difference in TIM‐3 expression level may be partly responsible for the functional discrepancy of CD38KORV and CD38KOTRACKI CAR‐T cells. The gene discussed is HAVCR2; the disease is acute lymphoblastic leukemia.