Moraxellaceae-dominant microflora caused a higher risk of asthma worsening as well as eosinophil activation, and in vitro experiments showed that Moraxellaceae induced epithelial cell damage and elevated the levels of the inflammatory factors IL-33 and IL-8 (McCauley et al., 2019; Chun et al., 2020). The gene discussed is CXCL8; the disease is asthma.