B. fragilis, typically depleted in Mtb infections, was found to be a key up-regulator of lnRNA-CGB in mouse models and patients with active TB (Yang et al., 2022) LncRNA-CGB was found to epigenetically regulate IFNγ through interaction with enhancer of zeste homolog 2 (EZH2) (Yang et al., 2022). This evidence concerns the gene EZH2 and tuberculosis.