Human FcRn has been demonstrated to be a two-in-one attachment-uncoating receptor of E18, and we hypothesize that this receptor plays a similar role in E30 invasion, because siRNA knockdown of DAF alone does not prevent E30 invasion, but siRNA treatment of FcRn completely abolishes E30 infection, as previously mentioned (Vandesande et al., 2020; Chen et al., 2022). The gene discussed is FCGRT; the disease is infection.