FCGRT and Echovirus infectious disease: Although FcRn plays an important role in E30 viral decapitation and is a necessary receptor for E30 invasion, studies have demonstrated that human FcRn expression is insufficient to infect echovirus through an in vivo pathway of the gastrointestinal tract; Type I IFN is a major driver of echovirus transmission from the gastrointestinal tract to secondary sites, including the liver and pancreas; and Type III IFN inhibits persistent echovirus infection in gastrointestinal epithelial cells (Wells et al., 2021, 2022).