PPARA and Parkinson disease: As nuclear receptors, PPAR signaling pathways (PPARs) are expressed in neurons and astrocytes of the central nervous system, and studies have confirmed that PPARs can play a neuroprotective role against oxidative damage, apoptosis, and neuroinflammation during the progression of PD (Heneka and Landreth, 2007; Iranpour et al., 2016).