After using receiver operating characteristic (ROC) evaluation, we found that among the above intersecting genes, DUOX2, ATG7, TLR4, DNAJB6, IL6, SLC11A2, CIRBP, FADS2, PTGS2, AIFM2, PROM2, CHMP6, FZD7, SOX2, and ENO3 had an area under the curve >0.7, suggesting that the above 7 target genes have high predictive value in PD induced by the progression of ferroptosis. This evidence concerns the gene DUOX2 and Parkinson disease.