Of the significantly enriched pathways in the CM vs CF group, extracellular matrix (ECM)-receptor interaction, calcium signaling pathway, PI3K-Akt signaling pathway, focal adhesion and cytokine-cytokine receptor interaction were of interest to our study as they could help understanding the sexual dimorphism seen in cell adherence which further contributes to the difference seen in differentiation (Table S1). The gene discussed is PIK3CA; the disease is cystic fibrosis.