Calretinin was positive in 39% of schwannomas including one case of cellular schwannoma and negative in all (100%) cases of neurofibroma while the differential expression of calretinin between schwannoma and neurofibroma groups was found to be statistically significant (p < 0.005).<h4>Conclusion</h4>Our study shows that S-100 does not show differential expression between schwannomas and neurofibromas. This evidence concerns the gene CALB2 and plexiform neurofibroma.