MOA: mechanism of action, OV: oncolytic virus, IL-12: interleukin-12, NK: natural killer cells, HSV: herpes simplex virus, TNBC: triple-negative breast cancer, GM-CSF: granulocyte-macrophage colony-stimulating factor, DCs: dendritic cells, GIT: gastrointestinal, IFN-B: interferon beta, VSV: vesicular stomatitis virus, HCC: hepatocellular cell carcinoma, AML: acute myeloid leukemia. The gene discussed is IFNB1; the disease is hepatocellular carcinoma.