The link between oxidative stress, CKD, and its complications is mediated by various mechanisms, such as increased nicotinamide adenine dinucleotide phosphate-oxidase (NADPH oxidases (NOX) activity), uremic toxin-induced endothelial nitric oxide synthase (eNOS), and decreased antioxidant defenses (5–7). This evidence concerns the gene NOS3 and chronic kidney disease.