METTL14 and type 2 diabetes mellitus: Gene expression analysis in whole islets collected from healthy humans and patients with T2DM revealed a down-regulation of several m6A regulators in diabetic individuals – methyltransferase METTL14, demethylases FTO and ALKBH5, and readers YTHDF1 and YTHDF3. In addition to transcripts, protein levels of methyltransferases METTL3 and METTL14 were also decreased (65).