The lack of a significant difference in the prevalence of any non-endocrine lesions between MEN1 mutation-positive index cases of the F-MEN1 (n = 47) and the S-MEN1 (n = 10) cohort seems to confirm previous findings, suggesting a putative role of MEN1 mutations in the classic phenotype of MEN1 syndrome, including the occurrence of related non-endocrine manifestations. Here, MEN1 is linked to multiple endocrine neoplasia type 1.