Although some studies reported a tumor suppressor role for MEN1 in sporadic melanomas, the relatively high prevalence of this malignancy in the general population and the lack of evidence of a somatic hit in resected melanoma of MEN1 patients suggest that the occurrence of melanomas in MEN1 syndrome may be incidental (69, 70). The gene discussed is MEN1; the disease is multiple endocrine neoplasia type 1.