The significantly higher prevalence of angiofibromas in our familial compared to sporadic MEN1 cohort, observed in both the whole and index cases, was expected due to the association between MEN1 mutations and familial MEN1 cases (94% F-MEN1 mutation-positive vs. 19% S-MEN1 mutation-positive, p < 0.00001). This evidence concerns the gene MEN1 and Angiofibroma.