Besides these two receptors, other GPCRs have been identified as promising targets for metabolic diseases, including the SCFA receptors, free fatty acid receptor 2 (FFAR2; alternate name GPR43) and free fatty acid receptor 3 (FFAR3; alternate name GPR41), the LCFA receptors, free fatty acid receptor 1 (FFAR1; alternate name GPR40) and free fatty acid receptor 4 (FFAR4; alternate name GPR120) and the bile acid receptor, GPBAR1 (26). This evidence concerns the gene GPBAR1 and metabolic disease.