PTN and Obesity: Moreover, recent reports have evidenced that PTN is implicated in the regulation of peripheral metainflammation, metabolic homeostasis, thermogenesis, as well as insulin sensitivity in the peripheral tissues (11, 56, 57) Furthermore, Ptn deletion protects against neuroinflammation, mitochondrial dysfunction, and aberrant protein aggregation in a high fat diet (HFD) induced obesity model (47).