Moreover, recent reports have evidenced that PTN is implicated in the regulation of peripheral metainflammation, metabolic homeostasis, thermogenesis, as well as insulin sensitivity in the peripheral tissues (11, 56, 57) Furthermore, Ptn deletion protects against neuroinflammation, mitochondrial dysfunction, and aberrant protein aggregation in a high fat diet (HFD) induced obesity model (47). The gene discussed is PTN; the disease is obesity due to melanocortin 4 receptor deficiency.