Previous studies have shown that palmitic acid has an important effect on maintaining semen quality and improving sperm motility (22, 24, 26), and the present study also demonstrated that palmitic acid has a certain effect on salvaging spermatogenic damage with the help of asthenozoospermia-model mice, which also an important theoretical basis for the subsequent in-depth exploration of how palmitic acid enhances the mechanism of action of spermatogenesis through up-regulation of Ppara gene expression. The gene discussed is PPARA; the disease is Reduced sperm motility.