After adjusting for confounding variables (including age, sex, CRP, HGB, LDL-c, HDL-c, TG, HBA1c, FPG, HCT, diabetes, SBP, CKD, CHD, mental disease, CLD), similar results were obtained, that is, the relationship between BMI and stroke risk was non-linear in male participants and their relationship was not statistically significant in female participants. This evidence concerns the gene CYGB and congenital secretory chloride diarrhea 1.