In addition, we also excluded participants with CKD (n=11,398) for sensitivity analysis and found that their relationship remained non-linear in male participants and linear in females (adjusted age, sex, CRP, HGB, LDL-c, HDL-c, TG, HBA1c, FPG, HCT, HBA1c, hypertension, SBP, CKD, CHD, mental disease, CLD) (Table 4). This evidence concerns the gene CRP and congenital secretory chloride diarrhea 1.