Three plastin isoforms are expressed in vertebrates: PLS1 (I-plastin) is expressed in absorptive intestinal and kidney cells (12), PLS2 (LCP, LCP1, or L-plastin) is predominantly found in hematopoietic and cancer cells (1, 13, 14), while PLS3 (T-plastin) is ubiquitously expressed in all solid tissues (1, 15). The gene discussed is PLS3; the disease is cancer.