On the contrary, serum microRNA profiles from 15 members of Finnish families with four different PLS3 variants associated with osteoporosis, showed variation in the regulation of seven miRNAs; of these 2 upregulated miRNAs targeted DKK1 (70), and they promoted osteogenic differentiation by blocking DKK1 (71). The gene discussed is DKK1; the disease is osteoporosis.