CYP11B1 and congenital adrenal hyperplasia: Thus, it can be speculated that 11-oxygenated androgens may contribute to the virilized phenotype in 46,XX CAH fetuses and that DEX-mediated suppression of 11-oxygenated androgens through the inhibitory effect on CYP11B1 could protect against adrenal androgenization of external genitalia.