ONECUT2 and prostate neoplasm: The Aldo-Keto reductase family members (AKR1C1, AKR1C3, AKR1C4, and AKR1C8P) AKR1C1 and AKR1C3 were among the highest upregulated genes in our OC2 network, and their expression increases with disease progression in prostate tumors (Figure 8C, left).