This finding coupled with evidence of reduced mitochondrial Ca2+ uptake and energy production in endothelial cell-specific MCUR1 nulls (Tomar et al., 2016) and vascular dysfunction in mice lacking MICU1 or MICU2 (Hoffman et al., 2013; Bick et al., 2017) suggests that excessive MCUcx activity in endothelial cells may contribute to impaired CBF and NVU damage in stroke. Here, MICU1 is linked to Stroke.