Loss-of-function mutations in MICU1 have been linked to a muscle and brain disorder characterized by muscle weakness, cognitive deficits, and abnormal involuntary movements including chorea, tremor, dystonic posturing, and orofacial dyskinesias (Logan et al., 2014; Bhosale et al., 2017; Mojbafan et al., 2020; Wilton et al., 2020; Kohlschmidt et al., 2021). The gene discussed is MICU1; the disease is Cognitive impairment.