Shexiang Baoxin pills can significantly reduce the frequency of angina attacks in CMVD patients, improve endothelial-dependent flow-mediated vasodilation (FMD) mediated by brachial artery flow, reduce serum Ang II, CRP, and ET-1 levels, increase serum NO level, and protect vascular endothelial function 28, 63. Here, EDN1 is linked to angina pectoris.