Tongxinluo capsule can improve the endothelial-dependent vasodilation mediated by brachial artery flow, increase the serum levels of NO and adiponectin, reduce the serum levels of ET-1, protect the vascular endothelial function in patients with CMVD, and then relieve the clinical symptoms of patients with angina pectoris 19, 60. Here, EDN1 is linked to angina pectoris.