Another hub-chemokine, CCL20, which showed the most gene alterations, was also found to be able to regulate the migration ability, epithelial-mesenchymal transition, and Akt phosphorylation in the human renal cell carcinoma cell line cells, and thus resulting in the poor prognosis of renal cancer 34. The gene discussed is AKT1; the disease is hereditary clear cell renal cell carcinoma.