A diagnosis of large cell neuroendocrine carcinoma (LCNEC) (cT2bN2M0, stage IIIA, programmed death‐ligand 1 [PD‐L1] tumour proportion score < 1%) was established through Endobronchial Ultrasound‐Guided Transbronchial Needle Aspiration, with an Eastern Cooperative Oncology Group Performance Status (ECOG‐PS) of 1. Here, CD274 is linked to large cell neuroendocrine carcinoma.