In addition, we synthesized siRNA against PAR2 to knock down PAR2; the combination of UA plus si-PAR2 significantly downregulated PI3K, AKT, and NF-κB gene transcripts and protein expression, and significantly decreased inflammatory cytokine levels compared with those of the hyperuricemia group (Figure 4(a)–4(d)). Here, NFKB1 is linked to hyperuricemia.