Various proteins are involved in the pathogenesis and progression of cancers, including survival-associated signaling kinases with relatively common mutants (e.g., BRAF V600E and KRAS G12D) (Cisowski et al., 2016), DNA damage repair response molecules (e.g., p53 and Rad51) (Bonilla et al., 2020), and cell cycle progression-associated compounds (e.g., Rb1 and CDK4/6) (Fassl et al., 2022). This evidence concerns the gene CDK4 and cancer.