CD274 and neoplasm: The improved PFS was independent of the LAG-3 or PD-L1 expression status and was present across all prespecified subgroups.5,37 It is worth noting that patients who had baseline characteristics that are usually associated with worse prognosis, including visceral metastases, high tumor mutation burden, increased serum lactate dehydrogenase, having mucosal melanoma, showed a superior outcome with combination therapy when compared to single-agent nivolumab.