CD274 and neoplasm: Interestingly, while treatment with antibodies targeting TIM-3 alone did not affect tumor growth and treatment with anti-PD-L1 antibodies showed delayed tumor growth, treatment with antibodies targeting both resulted in a significant tumor growth reduction whereby almost half of mice showed complete regression of their tumors.60 This suggested that increased expression of TIM-3 in TIL might have a promising predictive and prognostic value.