To investigate the prognostic value of PRKRA in PC, the KM plotter indicated that the overall survival was much better in the PRKRA-low group in both the clinical cohort [HR = 1.61 (1.03–2.53), P = 0.008] and TCGA database [HR = 1.76 (1.16–2.67), P = 0.008] (Fig. 1E and F). The gene discussed is PRKRA; the disease is pachyonychia congenita.