IFNG and neoplasm: Furthermore, gene ontology (GO) pathway analysis using clusterProfiler (71) showed T cell activation and response to IFNγ among the top GO pathways enriched in pt115 pre-REP TIL clonotypes in the original tumor, whereas pathways related to cytokine production and T cell differentiation were found in the original REP TIL clonotypes (Supplementary Fig. S15A).