T cells with RCC-associated motifs in pt115 were concentrated in the CD4+ TFH compartment (cluster 7), pt423 displayed a CD8+ TEXH cell phenotype (cluster 1), and pt616 displayed the CD8+ TPRE-EXH phenotype (cluster 2; Fig. 6D; Supplementary Fig. S15C). The gene discussed is CD4; the disease is renal cell carcinoma.