Next, to prune out the TCRs that were unlikely to target RCC-associated antigens, we filtered out motifs that were also found in the PB samples of healthy donor CD4+ (n = 37), CD8+ (n = 37) sorted T cells (34), those from patients with rheumatoid arthritis (ref. 44; n = 37), and motifs associated with 80 different viral epitopes from VDJdb (ref. 51; Fig. 4A). Here, CD8A is linked to renal cell carcinoma.