IRAG1 and coronary artery disorder: Of note, inositol 1,4,5-trisphosphate receptor-associated cGMP-kinase substrate (IRAG), which represents a downstream effector of cGMP specifically in modulating platelet activity, is encoded by the IRAG1 (ref. 13) (previously IRAG or as human homolog MRVI1) gene and has also been associated with CAD by GWAS14.