From a genetic perspective, private mutations in the genes encoding for sGC and rare coding and common noncoding variants in the GUCY1A1 gene, which encodes the α1-subunit of the sGC, were all associated with CAD or premature MI by exome sequencing and genome-wide association studies (GWAS), respectively4,5. This evidence concerns the gene GUCY1A1 and coronary artery disorder.