Therefore, we tested whether the rs7692387 genotype is associated with ANGPT1 release from platelets in healthy human individuals (n = 5 each; for characteristics see Supplementary Table 3) and found that homozygous carriers of the CAD risk allele G display lower ANGPT1 release compared to heterozygous or homozygous carriers of the non-risk allele (4.5 ± 0.7 versus 8.3 ± 1.4 ng ml−1, P = 0.04; Fig. 3f). The gene discussed is ANGPT1; the disease is coronary artery disorder.