Additionally, in small cell lung cancer, statins induced oxidative stress accumulation and apoptosis through suppressing the geranylgeranyl diphosphate (GGPP) synthase 1 (GGPS1)-RAB7A-autophagy axis, overcame both intrinsic and acquired chemoresistance in vivo across PDX models bearing high GGPS1 levels (Guo et al., 2022). The gene discussed is GGPS1; the disease is small cell lung carcinoma.