JAK2 and neoplasm: Moreover, in myeloproliferative neoplasms (MPN), aberrant JAK2 signaling plays a crucial tumor-promoting role, while JAK inhibitors did not induce patient remission; alternatively, simvastatin, lovastatin and atorvastatin inhibited mutated JAK2 localization to lipid rafts, consequently inhibited JAK2-V617-dependent growth and induced apoptosis in MPN cells, and suppressed primary erythroid colony formation of primary cells from MPN patients (Griner et al., 2013).