The immunotoxin hD7-1(VL-VH)-PE24mut retained PSMA specificity and high cytotoxicity on different prostate cancer cells with IC50 values in the picomolar range with a 3.3- to 4.6-fold reduced cytotoxicity compared to hD7-1(VL-VH)-PE40 (Michalska et al., 2018). This evidence concerns the gene FOLH1 and Familial prostate cancer.