On the other hand, to avoid LMP, tumor cells can overexpress cytosolic protease inhibitors and translocate HSP70 from the cytoplasm to the lysosomal lumen, or promote the binding of HSP70 to an endolysosomal anionic phospholipid bis(monoacylglycero)phosphate and acid sphingomyelinase activity, thereby maintaining lysosomal stability and protecting themselves (Silverman et al., 1998; Nylandsted et al., 2004; Kirkegaard et al., 2010). Here, PDLIM7 is linked to neoplasm.