CTSD and neuroblastoma: C1 can specifically bind to TFEB and promote its nuclear translocation, thus increasing the protein levels of LAMP1, LC3B-II, and CTSD in the human neuroblastoma cell line SH-SY5Y; also, C1 can enhance autophagy in N2a mouse neuroblastoma cells and Hela human cervical carcinoma cells through the key autophagy genes, ATG5 and Beclin 1 (Song et al., 2016).