Also, it was found that curcumin effectively restored the ability of CD8 cytotoxic T cells to lyse tumor cells, boosted T cell proliferation, and increased the production of tumor-infiltrating lymphocytes and effector cytokines, while decreasing the expression of PD-1, TIM-3, inhibitory immune checkpoint receptors, and their ligands in the tumor microenvironment, suggesting re-activation of exhausted CD8+ T cell responses. The gene discussed is CD8A; the disease is neoplasm.