TTR and neoplasm: Oyanguren et al. found that, on the one hand, curcumin induced ER stress and thus caused uncontrollable unfolded protein response and calcium release, which in turn impaired the stability of the mitochondrial compartment and induced apoptosis; additionally, curcumin could mediate the activation of caspase 8 via CTS and calpains, which in turn induced LMP, leading to disruption of mitochondrial homeostasis; both two pathways mutually acted to boost tumor cell death (Sala de Oyanguren et al., 2020).