STAT3 and neoplasm: Hayakawa et al. unveiled (Hayakawa et al., 2020) that curcumin restored the activity of dendritic cells targeting activated STAT3 and stimulated T cell activity in tumor cells and immune cells to strengthen tumor antigen-specific T cell responses, and synergistic treatment with curcumin and anti-PD-1/PD-L1 improved anti-tumor activity.