APP and Cognitive impairment: One of the main components of tea polyphenols, EGCG, has been studied for its potential in regulating β-Secretase, γ-Secretase, and amyloid precursor protein (APP) to reduce toxic levels of Aβ (Payne et al., 2022; Pervin et al., 2018; Yuksel & Tacal, 2019; Mazumder & Choudhury, 2019) Through hydrogen bond interactions, EGCG can alter the shape of Aβ42 and disrupt Aβ42 protofibril, thereby reducing the formation of Aβ42 plaques in the brain (Zhan et al., 2020) Animal experiments have also shown that EGCG can significantly improve cognitive impairment in aged rats (Wei et al., 2019).