Moreover, the previous research indicated that PIMREG overexpression significantly activates NF- κB signaling and promotes breast cancer aggressiveness, and the immune infiltrates associated with the upregulation of PIMREG in BC require further investigation (Jiang et al., 2019), and potential therapies targeted to PIMREG in BC need to be developed. The gene discussed is PIMREG; the disease is breast cancer.