Meanwhile, apoptosis-related protein cleaved caspase-3 within neuronal cells showed obviously downregulated expression in CUR-OM-MSCs co-cultured group, compared with the native OM-MSCs co-cultured group (Fig. 2G–H; 0.123 ± 0.012 vs 0.247 ± 0.029, p < 0.05). This evidence concerns the gene CASP3 and ocular melanoma.