Cancer progression is considered to be associated with genetic mutation of cells and aberrant functioning of mutated genes including BRAF, EGFR, HER2, KRAS, PHF5A, MET, and TP53, etc. Modification of treatment strategies in a way of targeting these molecules/therapeutic targets plays an essential role in preventing the growth, progression, and metastasis of tumors [22]. Here, PHF5A is linked to cancer.