FMOD and osteoarthritis: This suggests that cleavage of fibromodulin occurred at the site where the molecule is bound to collagen fibrils, while following FMOD cleaved, the fibrillar network was altered to lead to the exposure of sites which was subsequently confirmed by the cleaved type II collagen fibers (65, 66).On the other hand, complements have been found in significantly increased abundance in OA synovial fluid (129) and play a key role in OA synovial fluid in the pathogenesis of osteoarthritis (60).