This evidence expands to AUF-1 targets in the SASP secretome: established targets and COPD determinants such as IL-1β (43), IL-6 (114) and, IL-8 (192) but also the newly identified AUF-1 targets that were found within the human SASP secretome atlas (30). This evidence concerns the gene CXCL8 and chronic obstructive pulmonary disease.