CD8A and neoplasm: suggested that IL-10 participates in effective antitumor immune surveillance through several basic mechanisms, including by increasing the count of intratumoral tumor-specific cytotoxic CD8+ T lymphocytes, promoting the secretion of the cytokine IFN-γ from Th1 cells and granzyme from CD8+ T lymphocytes, improving the activity antigen presentation machinery and thus inhibiting tumor growth (Figure 5B) (170).